Metabolic Mechanisms of Failure of Intraportally Transplanted Pancreatic -Cells: Role of Lipotoxicity
نویسندگان
چکیده
From the Gifford Laboratories of the Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8854; Department of Cell Physiology and Metabolism, University Medical Center, 1 rue Michel Servet, 1211-Geneva 4, Switzerland; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390; Veterans Affair Medical Center, Dallas, TX 75216; †Present address: Department of Biochemistry, Chonbuk National University Medical School, Chonju, 561-756, Chonbuk, Korea
منابع مشابه
Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin.
The objective of this study was to determine whether the late failure of beta-cells in islets transplanted via the portal vein is caused by excess insulin-stimulated lipogenesis and lipotoxicity and, if so, whether the damage can be prevented by reducing lipogenesis surrounding the islets. Based on the premise that high portal vein levels of nutrients and incretins would stimulate hyperinsuline...
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